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Autism Spectrum Disorder (ASD) demonstrates high heritability, familial clustering and ~4:1 male to female bias, yet the causes are only partially understood, due to extensive clinical and genetic heterogeneity. Whole genome sequencing (WGS) promises added value to identify novel ASD risk genes, as well as new mutations in known loci, but an assessment of its full utility in an ASD group has not been performed.

Since Roentgen discovered x-rays in 1896, radiologists have had access to extremely powerful tools used to peer into a patient. Although x-rays are still used today, computers and other technological advancements have contributed to the development of extremely sophisticated medical imaging devices, such as CT, ultrasound, MR and PET scans. Dr. Richard Breiman, UCSF Professor of Radiology, explains how several medical imaging examinations work. He discusses how they are interpreted, as well as the beneficial clues they provide, which may help solve medical mysteries and contribute to patient management. Recorded on 03/05/2014.

By the age of 40, nearly all people with Down syndrome have the plaques and tangles associated with Alzheimer's disease. Michael Rafii, MD, PhD joins William Mobley, MD, PhD to discuss why this occurs, the prevalence and progression of Alzheimer's disease, potential treatment models and current research affecting this predisposed population.

Dr. Robert Baron, Professor of Medicine at UCSF, explains the prevalence of obesity and the trends in the rates of obesity then looks at what to do. He takes a look at various popular diets along with surgical and medicine options and concludes that the goal is to be as fit as possible at your current weight and present further weight gain, then begin weight loss. Recorded on 05/30/2014.

Adverse drug events are not uncommon in the community and result from inappropriate and appropriate use of medications. While adverse drug events and errors have been studied extensively in the inpatient setting, little is known on why they occur once the patient is at home. Zlatan Coralic, UCSF Department of Clinical Pharmacy, discusses how medications are chosen based on their known risks and benefits, and common adverse drug events and errors. He also presents research examining root causes of adverse drug events in the community. Recorded on 07/10/2014.

W.H. and Marie Wattis Distinguished Professor and Chair of UCSF Department of Pediatrics, Donna Ferriero, MD, MS, describes the injury and evolution in newborn brain, potential therapies for neuroprotection, and shows how MRI can help delineate injury and repair.
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