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Choosing residential care for a loved one if often a difficult decision. Linda Cho, executive director of Stellar care, joins William Mobley, MD, PhD to talk about the new models of residential care, family involvement, care with dignity and more.

What does sex have to do with human reproduction? Within the next 20 to 30 years or so, perhaps not much. At least that's how Henry T. Greely sees it. He's the Director of the Center for Law and Biosciences at Stanford University. He's also the author of a new book called The End of Sex and the Future of Human Reproduction. In this edition of Up Next, Greely talks about the coming revolution in reproduction, which, he says, will not only increasingly divorce sex from making babies, but also give parents more and more control over what genes their children will have. Recorded on 05/11/2016.

Over the last 30 years predictions of climate change as a threat to individuals, societies and nations have changed from possibilities to realities. Ethical issues associated with which individuals, companies, nations cause climate change, who might benefit from it, and who will suffer from the impacts have been part of the discussion from the beginning. How has thinking about the ethics of climate change evolved during that time and how does this relate to the ethics of extreme mitigation efforts like climate engineering? Margaret Leinen, UC San Diego Vice Chancellor for Marine Sciences, Director of Scripps Institution of Oceanography, and Dean of the School of Marine Sciences discusses what can be done, what is being done, and the ethical implications of deploying solutions.

Cellular modeling may hold the key to unlocking some the most important questions about autism. Alysson R. Muotri, PhD joins William Mobley, MD, PhD to explain how his work is shedding light on not only the pathology of autism but potential new drugs.

For the past three decades the largest family in the world with a genetic form of Alzheimer's disease has been tracked. This extended family of some 5,000 individuals live in Antioquia, Colombia among a people who call themselves Paisa. Passing relentlessly through the generations with 100% penetrance is a mutation that causes early onset Alzheimer's disease in its carriers. Dr. Kenneth Kosik explains that the mutation in the Americas likely originated from a Spanish conquistador whose progeny are the members of the family we see today. Recently, interest in the family has grown because they are now participating in a clinical trial intended to delay the onset of the disease. Recorded on 06/30/2016.

Statistics is the science of data: measuring and assessing uncertainty and more generally, learning from data. Since scientific, technical, and social disciplines all need to make conclusions based on data, statistics provides them with tools essential for their advances. From player stats to computer models to simulate the effects of climate change statistics play a key role. Recorded on 02/27/2016.

Three fascinating presentations reveal how exploring changes during critical periods of brain development may lead to interventions, therapies and perhaps cures to conditions from learning disabilities to Alzheimer's Disease.

2016 Kavli Prize recipient Carla Shatz from Stanford University presents a lively exploration of how understanding early stages of neural development may be leading to a pathway for developing treatments for Alzheimer's Disease. Recorded on 12/02/2016.

Nina Jablonski explores the nature and sequence of changes in human skin through prehistory, and the consequences of these changes for the lives of people today. Recorded on 03/01/2017.
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