Stalking an Alzheimer Gene Mutation in the Far Mountains of Colombia

11/10/2016; 28 minutes

For the past three decades the largest family in the world with a genetic form of Alzheimer's disease has been tracked. This extended family of some 5,000 individuals live in Antioquia, Colombia among a people who call themselves Paisa. Passing relentlessly through the generations with 100% penetrance is a mutation that causes early onset Alzheimer's disease in its carriers. Dr. Kenneth Kosik explains that the mutation in the Americas likely originated from a Spanish conquistador whose progeny are the members of the family we see today. Recently, interest in the family has grown because they are now participating in a clinical trial intended to delay the onset of the disease. Recorded on 06/30/2016. (#31481)

Links & Resources

More Programs With

 

SIGN UP FOR EMAIL UPDATES
Subscribe to receive email notifications about featured videos.
(c)2019 Regents of the University of California. All right reserved. Terms and Conditions of Use.