Building the Brain
The Muotri group at the Sanford Consortium for Regenerative Medicine and other collaborators are working with brain organoids – using an array of different methods and tools to find ways to reveal how a brain is built, so we can see how things work, how things go wrong, and how we can make those things go right. We’ll be visiting with them to see how brain organoids can help us do these things as we explore "Building The Brain."
Beginnings in the Brain: Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development
A detailed overview of a study conducted by Alysson Muotri's lab at the UC San Diego Stem Cell Program which found complex network signaling developing in human cortical organoids that appear to recapitulate fetal brain development, offering an in-vitro model to study functional development of human neuronal networks.
Making Brain Organoids: A Primer
Brain organoids, or cortical organoids, hold much promise in finding interventions for neurological conditions, and have already proven useful in understanding the effects of Zika and rare neurological syndromes such as AGS. But how are they made? UC San Diego Stem Cell program project scientist Cleber Trujillo provides a brief overview of how the Muotri lab nurtures pluripotent stem cells into becoming brain organoids.
3D Printing with Stem Cells - Shaochen Chen
Bioengineer Shaochen Chen has developed a method of 3D printing live human tissue that could one day be used to heal damaged spinal cords, hearts, and other vital organs. And, because his technology uses stem cells, the transplant tissue can be patient specific. Now, he's using his technique to help researchers Alysson Muotri and Karl Wahlin understand brain and eye development.
Neurobot: Robotics Meets Stem Cells
High school student Christopher Caligiuri teams up with renowned stem cell researcher Alysson Muotri to build a robot that interprets signals from lab-grown mini-brains.
Connecting Stem Cell-Derived Brain and Eye Models with 3D Printing
Top scientists are growing miniature brains and retinas from stem cells in their labs, and connecting them with 3D printed tissue. The team is hoping to gain new insight into the earliest stages of brain and eye development, in order to cure a whole host of diseases.
Stem Cells and Curing Blindness - Karl Wahlin
Scientist Karl Wahlin is hoping to use the tiny retinas he's developed from stem cells to find a cure for blindness. Wahlin has teamed up with UC San Diego Stem Cell Program Director Alysson Muotri, who is using a similar technique to study the brain. Together, they hope to understand how the brain and the eye influence one another's development.
Building The Brain With Alysson Muotri
Alysson Muotri, Director of the UC San Diego Stem Cell program explores the many ways his and other labs are using brain organoids to understand neurodevelopment.

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