The Stem Cell Channel
Stem cell science is changing medicine and our understanding of human development. The Stem Cell Channel takes you into the labs where cutting edge-research takes place, introduces you to the scientists leading the way, and breaks down how these amazing discoveries impact everyday life and health.
Making Pluripotent Stem Cells
9/13/2019
With the capacity to form any tissue in the human body, induced pluripotent stem cells, or iPSCs, are critical to the work of the UC San Diego Stem Cell program in studying disease and potential cures - but how are they made? This short primer outlines the basic steps to how these special cells are derived.
Beginnings in the Brain: Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development
8/28/2019
A detailed overview of a study conducted by Alysson Muotri's lab at the UC San Diego Stem Cell Program which found complex network signaling developing in human cortical organoids that appear to recapitulate fetal brain development, offering an in-vitro model to study functional development of human neuronal networks.
Making Brain Organoids: A Primer
7/31/2019
Brain organoids, or cortical organoids, hold much promise in finding interventions for neurological conditions, and have already proven useful in understanding the effects of Zika and rare neurological syndromes such as AGS. But how are they made? UC San Diego Stem Cell program project scientist Cleber Trujillo provides a brief overview of how the Muotri lab nurtures pluripotent stem cells into becoming brain organoids.
3D Printing with Stem Cells - Shaochen Chen
7/29/2019
Bioengineer Shaochen Chen has developed a method of 3D printing live human tissue that could one day be used to heal damaged spinal cords, hearts, and other vital organs. And, because his technology uses stem cells, the transplant tissue can be patient specific. Now, he's using his technique to help researchers Alysson Muotri and Karl Wahlin understand brain and eye development.
Mouse and Human Induced Pluripotent Stem Cell Models of Autism Associated with
Early Brain Overgrowth
7/25/2019
Tony Wynshaw-Boris, MD, PhD describes his lab's efforts to use mouse and IPSC models to find commonalities that give insight into the complex disorder of autism.
Neurobot: Robotics Meets Stem Cells
7/16/2019
High school student Christopher Caligiuri teams up with renowned stem cell researcher Alysson Muotri to build a robot that interprets signals from lab-grown mini-brains.
Connecting Stem Cell-Derived Brain and Eye Models with 3D Printing
7/10/2019
Top scientists are growing miniature brains and retinas from stem cells in their labs, and connecting them with 3D printed tissue. The team is hoping to gain new insight into the earliest stages of brain and eye development, in order to cure a whole host of diseases.
Stem Cells and Curing Blindness - Karl Wahlin
7/2/2019
Scientist Karl Wahlin is hoping to use the tiny retinas he's developed from stem cells to find a cure for blindness. Wahlin has teamed up with UC San Diego Stem Cell Program Director Alysson Muotri, who is using a similar technique to study the brain. Together, they hope to understand how the brain and the eye influence one another's development.
Gene Edited Cells: Next Generation of Cancer Therapeutics
6/30/2019
Khalid Shah, MS, PhD discusses translating biological therapies into clinical care.
Building The Brain With Alysson Muotri
6/22/2019
Alysson Muotri, Director of the UC San Diego Stem Cell program explores the many ways his and other labs are using brain organoids to understand neurodevelopment.
When Science Meets Fiction - Alysson Muotri, Tim Disney and the Movie "William"
6/15/2019
The science of stem cells allows us to understand our genome by comparing our own genome to that of our ancient cousins – the Neanderthal.

The motion picture William is a story about a Neanderthal living among modern humans. The director of the UC San Diego Stem Cell Program Alysson Muotri was able to visit with the creator and director, Tim Disney, to discuss the real issues explored by this fantasy.
Neanderthal Among Us? Science Meets Fiction - A Discussion of Tim Disney's Motion Picture "William"
6/8/2019
What makes us human is a question that not only science asks, but all disciplines of mind from philosophy to religion to sociology and ethics, and even to storytelling and the arts. Tim Disney's new movie "William", about a Neanderthal living in the modern world forces us to ask that and many other questions. Director of the UC San Diego Stem Cell Program Alysson Muotri brought together a panel of experts from across a spectrum of disciplines to discuss those issues in...
Curing Leukemia: From Zebrafish to Alpha Clinics
5/31/2019
Alysson Muotri explores how discoveries made using tiny Zebrafish will lead to cures for blood diseases like leukemia using stem cells, and how those cures will reach patients through California's network of Alpha Clinics.
From Zebrafish to Leukemia
5/25/2019
David Traver explores how discoveries made using tiny Zebrafish will lead to cures for blood diseases like leukemia using stem cells.
Is Most of Your DNA Junk?
5/24/2019
Alysson Muotri and top geneticists Rusty Gage and Miles Wilkinson explore the fact that ninety-nine percent of human DNA doesn't code for anything used by the human body.
California's Alpha Clinics: Bringing Science to the Clinic, Creating Cures for You
5/22/2019
Alysson Muotri and Catriona Jamieson discuss how cutting-edge stem-cell-based cures will reach patients through California's network of Alpha Clinics.
The Piwi-piRNA Pathway: A New Paradigm of Gene Regulation with Haifan Lin
5/17/2019
Professor at Yale University and the founding director of the Yale Stem Cell Center Haifan Lin talks about how the discoveries of small non-coding RNAs, including PIWI-interacting RNAs (piRNAs), have significantly expanded the RNA world.
Re-constructing Brains in the Lab to Revolutionize Neuroscience - Exploring Ethics
3/23/2019
Cerebral organoids, also known as mini-brains, are tridimensional self-organized structures derived from stem cells that resemble the early stages of the human embryonic brain. This new tool allows researchers to explore fundamental neurodevelopmental steps otherwise inaccessible in utero experimentally. Alysson Muotri, UC San Diego Stem Cell Program, explains how mini brains are generated in his lab and how this strategy can create novel therapeutical insights on neurogenetic...
Development of Therapeutic Approaches for Muscle Disease Using Human Pluripotent Stem Cells
3/7/2019
April Pyle, Department of Microbiology, Immunology and Molecular Genetics at UCLA, uses multi-disciplinary approaches to study human pluripotent stem cell biology and differentiation of these cells for use in regenerative medicine. She studies both basic aspects of stem cell biology as well as more translational aspects of human pluripotent stem cell differentiation towards skeletal muscle for use in therapeutic approaches for patients with muscular dystrophy.
Ethical Boundaries of Research with Human Embryos - Exploring Ethics
10/31/2018
Since stem cells were first cultured from human embryos in 1998, the ethical considerations surrounding this technology have been widely debated, leading to establishment of limits on how this research is conducted and funded. Learn more about these scientific advances, the implications of these discoveries for human health, and consider how ethical norms can best be integrated into research and practice. Recorded on 10/03/2018.
 

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